Publications

About

Welcome to the publications section of the International Advisory Committee on Clinical Trials in Multiple Sclerosis (IACCTMS). Here, you will find a collection of the committee’s published works, including research papers, guidelines, and reports aimed at advancing the understanding and treatment of multiple sclerosis (MS).

Publications

11 June 2025 I Course Descriptors Meeting

Rethinking the Way We Define MS

Rethinking the Way We Define Multiple Sclerosis: A Step Toward Biologically-Based Course Descriptors

19 February I Frontiers in Neurology

Priority Setting: Women’s Health Topics in Multiple Sclerosis

9 AUGUST 2023 I MS Journal

Improving the Efficiency of Clinical Trials in Multiple Sclerosis

9 AUGUST 2023 I MS Journal

Enhancing Involvement of People with Multiple Sclerosis in Clinical Trial Design

9 AUGUST 2023 I MS Journal

Assessing Heterogeneity of Treatment Effect in Multiple Sclerosis Trials

9 AUGUST 2023 I MS Journal

Enhancing Diversity of Clinical Trial Populations in Multiple Sclerosis

9 AUGUST 2023 I MS Journal

Intermediate Outcomes for Clinical Trials of Multiple Sclerosis Rehabilitation Interventions: Conceptual and Practical Considerations

24 January 2023 I Conference

Improving Design and Inclusivity of MS Trials

January 2023 I The Lancet Neurology

Pioneer Framework Proposal to Reclassify Types of MS

Guidelines, Research Papers, and Reports

Please use the easy-to-navigate tab below to select your publication type (guidelines, research papers and reports)

IACCTMS Guidelines for Conducting Clinical Trials in Multiple Sclerosis

Authors: International Advisory Committee on Clinical Trials in Multiple Sclerosis
Year: 2024
Abstract: These guidelines provide standardized recommendations for the design, conduct, and reporting of clinical trials in MS, with the aim of enhancing the quality and comparability of research in the field.> Access here
Course Descriptors
o Defining the Clinical Course of MS (1996)
o Defining the Clinical Course of MS: 2013 Revisions (2014)
o The 2013 Clinical Course Descriptors for Multiple Sclerosis: A Clarification (2020)
Development of the Multiple Sclerosis Functional Composite (1999)
Diagnostic Criteria
- Diagnostic Criteria for MS (2001, 2005, 2010 and 2017) and Differential Diagnosis of MS (2008)
Guidelines for MRI in Monitoring MS Treatment (1996)
The Ethics of Placebo-Controlled Clinical Trials in MS (2001 and 2008)
Comorbidity in MS and its Impact on Clinical Studies (2014-2015): A Set of Comprehensive Systematic Reviews of Impact and Prevalence of Comorbidities in MS and recommendations for incorporating comorbidity analyses in Clinical Trials and Observational Studies

Outcomes Assessment in MS Clinical Trials – The “Charleston Meeting” (1995)
Workshop: Innovations in Clinical Trial Design & Enhancing Inclusivity of Clinical Trial Populations (2022)